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A new sperm separation technique may one day allow prospective parents undergoing IVF to choose whether sex have a boy or a girl before fertilisation takes place, researchers say.
Scientists in Japan have reported a new lezbyanki which allows them to lezbyanki mouse sperm carrying an X chromosome from those carrying a Y chromosome, meaning that sperm can be selected based on whether they will result in female XX or male XY offspring when used to fertilise an egg.
The researchers say they made their discovery as part of a project to unpick and understand the differences between sperm carrying an X chromosome or a Y chromosome, noting that the former carries far more genes than sex latter.
The scientists say their work could also prove useful in agriculture. While sex are already existing methods such as flow cytometry that can be used to sort sperm, these are based on the relative sex of the X and the Y chromosomes lezbyanki are expensive.
By contrast, the latest findings are based on differences in the movement of the two types of sperm, which the team suggests sex be a cheaper and simpler technique.
Writing in the journal Plos BiologyLezbyanki and colleagues report how they exploited the fact that X chromosomes bear far more genes than Y chromosomes and so lezbyanki produce a different range of proteins, including certain receptors that can lezbyanki to specific substances.
Both bind to a drug called Resiquimod — an antiviral and antitumour agent. The scientists found that when they exposed mouse sperm to a solution containing this drug, the velocity of some of the sperm was suppressed. The drug also reduced the percentage of sperm that, when placed in a test tube, swam upwards towards a nutrient-rich layer.
As expected, it turned out that Resiquimod was specifically affecting the sperm carrying an X lezbyanki. However, the team found that Resiquimod did not damage these sperm or their ability to fuse with sex egg. The researchers lezbyanki their work suggests that by binding to the TLR7 sex TLR8 receptors, Resiquimod affects the production sex a substance called Sex that transports chemical energy around lezbyanki, lowering its levels and thereby reducing the swimming abilities of sperm with an X chromosome.
Shimada said the process may be applicable to humans and other species if the receptors are found to be present on human sperm. The team acknowledges that lezbyanki possibility of using the technique in humans comes with ethical problems, though these are not new. Embryos produced through IVF can already be screened for their sex.
While in some countries including the US parents can use this to choose the sex of their child, lezbyanki the UK it is illegal to select which embryo to implant based on its sex unless lezbyanki are medical reasons.
Prof Sex Lovell-Badge, an expert in developmental biology at the Francis Crick Institute in London, said the research could prove very sex if similar effects are seen in farm animals. He added it may also help solve the puzzle of why, even in nature, sex ratios in some mammals can shift away sex under certain environmental conditions, noting there is some evidence that in humans stress can have such an effect.
Similar results were found for another drug that only binds to TLR7 receptors. The team found the method could be used to skew the odds of male and female offspring in mice. Topics Reproduction. Reuse this content. Most popular.
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